Not sure this series qualifies as "brilliant" per se, but it was a pretty clever concept and it sure was cancelled. Sid and Marty Krofft (the guys who concocted the trippy H.R. Pufnstuf) created D.C. Follies back in 1987, right before the presidential election. It was a satire of current events and politics but had puppets and Fred Willard. Oddly entertaining, it had potential to be a decent series if it had just been a little bit edgier or a little more biting. To me some of the then presumably lame jokes are kind of funnier in retrospect.