The Lizard
Raimi has said he wants to get around to this reptilian villain, especially since he's worked Dr. Curt Connors, Peter's one-armed science professor, into the first three movies. It's Connors' experiments at regrowing his missing limb that turn him into a six-foot, human-hating gecko. According to an insider who spoke to DHD, once they announce the villain, we'll know who's playing him. Now, that could indicate the already-present Dylan Baker, or it could indicate...

Man-Wolf
Played by Daniel Gillies in the second Spider-Man movie, John Jameson was the astronaut son of newspaperman J. Jonah Jameson, and the fiancé of Mary Jane Watson. Mary Jane left him for Peter, so we never got to see if he went back into space and discovered a mystical gemstone, one that turned him into a snow-white werewolf who fought Spidey. His return is always a possibility, but Gillies may not be a big enough name to carry the villain role, so the likelihood of it being him is slim. Still, werewolves are hot right now -- almost as hot as vampires! And speaking of vampires...

Morbius the Living Vampire
If director Sam Raimi's off-the-cuff remarks are to be taken at face value, he would love to make a movie about vampires. Specifically, living vampires. Like the Lizard, Dr. Michael Morbius was a scientist, this time with a blood disease, who tried to cure himself with his own animal experiments using vampire bats. You can guess how that ended up -- he turned himself into a living, breathing vampire. Now, Raimi is no stranger to horror films (Evil Dead, anyone?), but a vampire movie might take Spidey into an even darker direction than the last film. But not as dark as...

Carnage
Remember Venom? The symbiotic ooze that bonded with Spidey before finding a revenge-buddy in photographer Eddie Brock? Pretty creepy, right? Well, imagine if Venom bonded to a serial killer. Cletus Kasady was Brock's cellmate, who bonded with Venom's offspring to become the red-skinned mass murderer known as Carnage. The producers were already talking about a Venom spin-off movie -- he turned good for a while in the comics -- so why not simply have Spidey fight a new, more evil Venom? Of course, to do this character justice would be tricky -- Carnage is a stone-cold killer, and this Spidey adventure would get pretty bloody, pretty quick. You could kiss that PG-13 rating good-bye. (Also, Raimi has expressed a fondness for more classic Spidey villains, and Carnage is a fairly new addition to his rogues gallery.)

Now, any of these villains would be interesting to see, but there are some Spidey foes who would be even cooler. Check out our picks...