Frankenstein's Monster (Frankenstein)
The tale of how Henry Frankenstein reanimated a dead body with a criminal's brain inside it is an old one, and while the monster only killed three people in the 1931 movie, his trail of terror continued through a dozen sequels and spin-offs as he was re-animated again and again, and his body count was well into the double digits by the time it was over.

The Judas Breed (Mimic)
New York City had a cockroach problem, and entomologists had a solution: breed a new bug that can kill a cockroach. Except any bug that can kill a cockroach is a hardy breed indeed, and within a few years they had evolved into man-sized, highly camouflaged killers. If not for Charles S. Dutton, New York would have fallen to their armies. God bless you, Roc.

The Rage Virus (28 Days Later)
I don't know what the British scientists thought would happen when they made a bunch of monkeys watch disturbing images on the telly, but all it took was some misguided animal activists and the entire country (possibly the world) had fallen prey to the virus, with hordes of running zombies picking off the survivors.

The Raccoon City Disaster (Resident Evil)
The Umbrella Corporation has compounds around the world, but the Hive is their top-secret underground research facility, deep below Raccoon City. That's where the deadliest superviruses are developed, and you would think that a high-tech underground facility could keep such a virus contained if there were an outbreak. Well, you're wrong. Global outbreak.

Gravity Drive Test (Event Horizon)
Don't mess with black holes. Seriously. Sure, an artificial black hole is a great way to bridge two points in space time, making faster-than-light travel possible, but where does the ship go in between those two points? Apparently, it goes to another dimension where everything is pure chaos, and where gouging your own eyes out, tearing apart your crewmates and caking the walls with their remains is an acceptable response.

Monocane Poisoning (The Invisible Man)
Whether you're Kevin Bacon in The Hollow Man or Chevy Chase in Memoirs of an Invisible Man, invisibility is never as cool as it seemed when you were a kid. Either through chemical or psychological means, you will likely go insane and murder somebody, and nobody holds a candle to Claude Rains in the original 1933 film, who went on a killing spree in the middle of an English village.

The Clamp Enterprises Incident (Gremlins 2)
Gremlins are bad enough, with their multiplying and mutating, but don't ever set them loose in a science lab. By downing various genetic compounds (created by Christopher Lee, so you know they're dangerous), the Gremlins turn into even deadlier versions of themselves: a bat-Gremlin, a spider-Gremlin, an electrical Gremlin, a smart Gremlin, a lady Gremlin and, for some reason, a Gremlin made of vegetables.

Monster 01 (Godzilla)
Although Godzilla's nuclear origins are not clearly defined in his first appearance, making it possible for him to have been spawned by the American attacks on Nagasaki and Hiroshima, the 1998 American remake shows a lizard's nest getting irradiated by nuclear testing in French Polynesia. Presumably, that testing led to Godzilla's rampage through New York, and the greater disaster that was that film.

Jurassic Park (Jurassic Park)
Clone a brontosaurus if you have to. A stegosaurus or triceratops, sure, why not? But a velociraptor? A Tyrannosaurus rex? Stop me if I get too technical here, but are you high?

What's your favorite scientific disaster? Let us know below, then see why we think Jonah Hill always plays the same role.

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