Is genetic engineering rigidly regulated because of what we're worried the modified creatures will do to us, or what we'll do to the creatures? That may be the question Cube director Vincenzo Natali asks in his new film, Splice. Or he may simply be asking the question, "What if two kind of messed-up geneticists went off the reservation?" Because that's what happens in this film, and the situation they've created for themselves spirals out of control in a way that is frightening, sad and, at times, laugh-out-loud funny. But while some of the laughter comes from legitimately humorous moments, much of it comes from shock, as the film toes the line in several scenes then calmly strides right over it. Depending on how squeamish you are, the laughter may also manifest itself as squirming uncomfortably in your seat, and your feelings about the movie will have everything to do with whether or not that sounds like fun to you.