First of all, let's give a moment of thanks for scientific experiments, especially scientific experiments gone awry. Without them, movies would be much more boring. First of all, we would have very few superheroes: Spider-Man, the Hulk and the Fantastic Four wouldn't ever have existed. But even outside the world of superheroes, science is often the villain in movies, with cold logic warping the minds of the bad guys and reckless tampering with nature leading to bloodshed. The latter seems to be at play in the new genetic-modification horror film Splice, and we've been inspired to put together a list of some of our favorite scientific disasters in movies. Do not duplicate these tests!

Tags: 28 Days Later, Frankenstein, Godzilla, Jurassic Park, Mimic, Resident Evil, Splice

It looks like Marmaduke was less competition for the kiddie dollars than we expected, as Shrek Forever After still handily defeated all comers, moving into a few more theaters and scaring up another $25 million in ticket sales. I guess kids are no longer impressed by animals who don't have jobs? After all, why see a movie about a plain old dog when you can see a movie about a cat sword-fighter, or guinea-pig secret agents, or a mouse chef? (This may be why they're spinning Puss in Boots off into his own movie.) Maybe they should have called it Marley & Me 2: Puppy-Size Me!, and had Owen Wilson magically transform into Marley-maduke at the beginning of the film. Then it might have made $36 million in its opening weekend, like Marley, rather than the $11 million it did. Well, you know what they say: hindsight is a golden retriever. Rimshot!

Tags: box office, Get Him to the Greek, Killers, Marmaduke, Shrek Forever After, Splice