Brian tells Andrea she can't drink, because of the medical trial's strict rules. She says that having sex with him doesn't mean she changed her mind; it wasn't that mind-altering. He tells her that's just fine, but she needs to tell Brian Jr. that she has cancer and isn't doing anything about it, and then she can take Brian Jr. coffin shopping. Across the room, Letitia approaches Nola. She tells her she harbors no ill will toward her, but then she tells her that the whole thing with Jeremy was set up, so I'm thinking there's still lots of ill will there. Tripp's in another room telling Patrick that the agriculture committee will set him back years. He blames Nola's invoice, but Patrick says it has nothing to do with her. Tripp wants to know if Patrick has asked what Nola wants, but Patrick says she's the only one who doesn't want something, and that he should take his own advice from the toast and support Patrick for a change.
By the fireplace, Nick approaches Hot Roadkill and they make flirty small talk that could have been written in a third-grade classroom. Nick: "How's the boarder?" Hot Roadkill: "Far from bored." HR: "This dress ... I think it goes for 10 grand." Nick: "Nice." She also says how strange it must be to be around this all the time, and asks where his wife is. Cue Lisa's entrance. She tells him Simon showed her the disc. He says he can't do this right now, in that dismissive way Nick has with her, as if she's not the person he chose to love and honor above all others. She tells him he can, and he will. He grabs her and tries to lead her out, but she's already yelling about how he wanted to know if Karen was still pathetically waiting for him, and if they're on now. She says if "that slut, that rich disgusting stringbean made of money" is what he wants, he can have her because she's waiting for him, "wide open." Um, ew? I think. Karen tries to insult Lisa, but "I smell trouble, or is that your perfume?" really isn't an insult unless we assume that trouble smells bad. Which, yeah, it's a stretch. Lisa tells her to walk away. Karen says if she does that, Nick's just going to look at her ass. Nick says nothing, because he is a total dick. Lisa says Karen won't be happy until she sees Lisa and Nick's relationship die, and Karen says, "Well, he certainly won't." Lisa calls her a "stupid, slutty bitch" and throws a glass of champagne in her face. Nick yells at Lisa: "What the hell?!" Karen interrupts him and says she's never been in the same class as Lisa, but she's not afraid to fight above her weight. Lisa tells Karen she'll kick her ass... if she can find it. Did I miss something? Are these fat jokes? Is Lisa supposed to be fat? I must have missed that, in that SHE IS NOT. Brian says that now this is a family dinner. And, yes, I agree: my family, too. Not to this degree or anything, and not with this much money. But definitely with the dysfunction at family events. Lisa slaps Karen and it is awesome. Nick jumps in front of Karen and says it wasn't her fault. And I actually hate him. Jeremy jumps in and tells Nick to back off and listen to Lisa for once. Nick says it's not Jeremy's business, but he thinks it is, because Lisa's been cool with all of Nick's head games, but, and I must quote this, "even an art chick has got limits." Ha. Jeremy's view of the world. Nick asks Jeremy who he thinks he is to talk to him that way, and Jeremy says "your worst nightmare" sheepishly as he sort of shrinks away. Lisa tells them both to shut up. And Karen says to "just let the bitch be." Then she points at Lisa and is dragged off.