"There's one career all females have in common, whether we like it or not: Being a woman. Sooner or later, we've got to work at it, no matter how many other careers we've had or wanted."
Imagine you're Eric, looking in Jenny's sweet eyes, and saying, "I like you, and I like shopping, but I'm not Going Shopping With You." When all she's trying to do is connect with you? Impossible. She's your friend, she needs a gay BFF, you have to be The Gay BFF. You can't hate her for it, no matter how angry it makes you. But to be queer is first and foremost to fuck with the agreed-upon man/woman dynamic, just by existing. Even more harshly than the Serenas of the world, it's your job to play along and find your place in the game: Queer is a subset of Feminist, which means we all have more choices and more responsibility than we ever knew.
"The things you drop on your way up the ladder so you can move faster -- you forget you'll need them again, when you get back to being a woman."
Any system has rules, whether it's gender roles or heterosexuality or rich-dad/poor-dad class structure, and your option is to learn those rules and perform them properly, in order to be rewarded by that system -- get good grades and get into a good school and finish at the top of your class, and you'll be rewarded with money, for example -- but any system, social or otherwise, still operates in terms of game theory. You're making a deal, when you agree to the rules of the game, and that's what shame was invented to contain and administrate: to keep everybody playing the game. The reward and the price of being in free-fall, as Serena can tell you, is that the whores of the world get to make their own rules, because they're playing a different game altogether. Doesn't mean you can't pick and choose.
When Serena flips her pretty hair, she's no different from Chuck sidling up to Josh Ellis at the bar, or Eric walking stolidly to school with Little J hanging off him like a jungle gym. She's no different than Nate, willing to come off weak in order to play PJ into the trap of his masculinity. She's no different from PJ himself, whose balls were on the block the second Serena walked in. She's no different from Blair leveraging Chuck against her needs, or Vanessa playing all the cards she'll play tonight, or Olivia trying desperately to reconcile the two powerful women she needs to be. We're all strangers/We're all embers from the same fire. Just please never forget that we hate it as much as you do.