The somewhat good-natured Patient du Jour assures them that he doesn't have basketballs in his pants and he's not just happy to see them. Katherine gets her mom jeans on and scolds him for letting it get so bad before seeing a doctor. He claims he saw doctors before and they prescribed pills, but it's only gotten really severe in the last few months. His friend, who is a girl, claims that he's using severely painful enormously inflated balls as an excuse to avoid his ten-year high school reunion. Um, dude, didn't anyone tell you that those aren't mandatory. They aren't jury duty or military service. If you don't want to go, just don't go, elephantitus of the nuts or not. Katherine promises him he'll be able to go to the reunion with 98% less scrotum. He should definitely put "Now with 98% less scrotum!" on his OKCupid profile.
Today's Minnesota-based Patient du Jour is a heart patient who is in the hands of Cristina's Ancient One best friend. Obviously he has an outdated and invasive procedure planned while Cristina has less invasive and more technology-driven operation in mind. Luckily their relationship has improved to the point that Cristina can tease him about his age and out-datedness mercilessly ("You're a national landmark, like the Grand Canyon, only slightly older!") and he just laughs it off.
Meanwhile, turns out Meredith's intern (the once and future Mac from Veronica Mars) was right about the super rare tumor. The patient doesn't take the news particularly well, though, and starts sobbing like a little girl instead of the stalwart security guard they were expecting. Meredith assures him that they can take the tumor out. Elsewhere in the hospital, Derek is teaching the other interns how to put in central lines. They aren't especially excited by the prospect. Sure hope Derek's oh-captain-my-captain teaching method will inspire them to greatness.
Back in Minnesota, Cristina's reptilian boss/ sex friend, Parker, wants to know if she tried to convince the Ancient One to use a less invasive procedure. She assures him she did, but the Ancient One could not be convinced and Cristina's okay with it because his old school procedure has fewer potential side effects. Parker scoffs and tells her to "enjoy it while she can, which is vague but he won't elaborate, not even for his sex friend who could sue him for sexual harassment in an instant. ("He told me I had to fit in if I wanted to get off of probation.")