Meredith and Derek are working on another Alzheimer's patient, Ed, who is hooked into the now-familiar halo for his familiar-but-still-horrifying awake surgery. His pulse starts to go up and then alarms start to ring as he yells, "Not again!" Derek and Mere jump into action and start doing chest compressions as Mere wonders what on earth just happened.

Whatever happened, it didn't end well for Ed, who is wheeled out of the OR under a sheet while Meredith and Derek talk to Richard. He was fine before surgery and didn't appear to have a history of heart problems, so they have no idea what's up. Derek plans to file a report with the FDA, and Meredith wonders if the FDA could shut them down. In that ever-so-slightly haughty way of his, Derek declares that it doesn't matter, because he's going to shut the trial down himself until they can figure out what happened and why they didn't anticipate it.

After talking Callie down from her panic attack, Cristina goes off to find Dr. Stark; it seems she might not be the worst godmother in the world after all as she is trying to get him to allow Callie to see Sofia, thinking it would be good for both of them. Stark totally won't permit it until Sofia is off a ventilator and has an immune system. That seems fair enough, actually. He adds that he's all for mother-baby bonding but not when it might kill the baby. However, the sneering tone he uses when he spits out "bonding" seems to indicate that he finds the whole idea to be nonsense. He may have a heart now, but it still seems to be a tiny one that doesn't have much room inside for anything other than his own interests. With one parting shot about Cristina's doctoring skills he walks off, and we see that Avery has been witness to the whole scene. Cristina just thinks a moment, and then tells Avery she needs his help.