Meredith tries to quit therapy except she refuses to call it quitting and refuses to admit she quits anything, despite the fact that Dr. Amy points out all of the times she's tried to quit, up to and including when she tried to quit being alive. She and Derek have another clinical trial patient, a woman this time, who refuses to have her surgery until her boyfriend arrives at the hospital. The only thing is, given the evidence that her sister provides, it seems like the boyfriend doesn’t exist and is just a hallucination from the tumor. She breaks down and goes into surgery, and as they inject the virus someone comes in to tell them that the boyfriend has arrived. Unfortunately her brain swelled so much during surgery that she'll never wake up. But Meredith seems to finally have been shaken into realizing that love might be able to exist and that she's colossally screwed up, and she goes back to therapy. Derek, meanwhile, wanted to let the patient go on believing she had a boyfriend, thinking that was better for her than having to face the harsh reality. The harsh reality for him is that he doesn't want to talk to Rose, but when she finally pulls away he tells her he just wants to be happy and uncomplicated, and they wind up holding hands because Rose is spineless and won't send him away for being an ass.

Mark is trying to turn over a new leaf and be romantic rather than sexy, much to the disappointment of Callie, who desperately wants to get laid. The subject of a threesome comes up, and Callie teases Mark about wanting one with her and Hahn. When they all end up in the elevator together she teases him about it and Hahn tells him he could never handle it. To prove her point, she grabs Callie in a long kiss before leaving with a smirk, leaving Mark slack-jawed and ready for sex again, and Callie looking stunned and somewhat worried. Hahn might just be feeling good because she did a surgery on the Chief's mentor, who was a pioneer in the field of cardiothorasic surgery. She didn't want to do it and tried to refuse, but eventually Richard got her into the OR. She starts to freak out, but while she's yelling at Richard for ruining her career, she does the procedure without even thinking about it, so all is well. George has spent his day running around doing errands for the Chief, but has a nice moment with Richard's mentor where he tells George that he's doing a good job. George asks him to pass that along to Richard, and later Richard compliments him and sends his confidence back up to where he might really be able to make a good doctor one day. In all his running around, he also manages to smoothly get baby Tuck out of the way when Bailey and Tucker start to have a huge fight about their family that starts to reveal what the problems might have been that they never actually talked about before.

Izzie spends the day getting alternately getting yelled at by Alex and examining Ava, who still isn't pregnant but completely believes that she is. She also goes to Sloane to try and get a breast enhancement and he realizes that she might be having some sort of post-traumatic stress, so he tells Izzie to get a psych consult. Ava tells Izzie that she can say whatever she wants to Alex, so she tells him that his girlfriend isn't really pregnant. She gets yelled at for her efforts and I hate to say it, but I sided with her in this one since Alex really was an ass. Once he realizes that Izzie was telling the truth and that something is really wrong, he brings Ava home to care for her. And finally the other person being a big jerk is Cristina. She's still completely messed up over the Burke thing and instead of doing surgery or meeting the man who is a God in her chosen field, she chooses to update charts and cruelly insult George and Lexie. But the scariest thing -- the one thing that means she's really in a bad place -- is that she cleans her apartment. Looks like someone might need therapy even more than Meredith does.