Song still playing. Alex fills out a chart near Nurse Olivia of the Syph. He's all, "Still not talking to me?" She replies, "You gave me syphilis! And I am talking to you, I just don't have anything to say." She asks how George is. Alex says he's a whiny fetus, then pisses her off by saying it's no big deal he didn't tell her about the syph. She jerks the chart from him and walks off. They're so about to do it, but not before Izzie walks up and tells Alex she's on the quints case. Alex says he heard. Izzie says they're going to need multiple surgeries once they're delivered, so she put him on the pager list. Alex is less than thrilled with this information, which Izzie automatically translates to their "technical difficulties." "Was it me? We seemed to be having a normal time." Alex assures her that it wasn't her; he was just tired, and didn't feel like it. Izzie asks him if he feels like doing it tonight. Alex says he's on call. Ugh! Izzie, not taking no for an answer, is all, "Oookay, so do you feel like doing it now?" She backs away with the bedroom eyes, and Alex looks like he just might feel like doing it now.

George slams into the stairwell and finds Meredith sitting on the steps all forlorn. He tells her he's got to find a way to get in on the quints case. Mere says she's guessing she doesn't stand a chance, since it's Addison's case. George blurts, "Penis!" Mere sighs, and wonders why every guy she meets comes with his own unique set of nightmarish humiliations. George stutters, "Maybe it's a, a m-matter of volume?" Mere's like, "Oh, so now I'm a slut?" George says he thinks she's taking some risks, and one day she might find herself in a hole in someone's basement. And just as the song says it, George says, "Being ordered to put the lotion on its skin, or else you'll get the hose again." Brilliant. George goes on to say that Mere deserves better than meaningless one-night stands. "And hey. Not every guy's a nightmare." He does not add, "Like, say, one George 'Manly' O'Malley," but I wish he would. Mere thinks this over as we go to commercials.

We come back to Alex and Izzie making out in one of the doctor's rooms. They're just getting to the good part when Izzie's pager goes off. Stupid quints!