The Chief catches up to George in the hall and tells him he has his father's test results, and the pregnant pause and the music tell us it's not good. Cristina and George go into his father's room, where his brothers are playing cards. The interns say that they'll wait for the Chief to give them the results, but when the brothers begin to mock George for not being a real doctor himself, he snaps. "Ronny! I am a doctor. Just not Dad's doctor." He kind of says it to his coat, though, lessening the impact. His dad realizes something is wrong, but George wants to wait. Cristina starts to tell George quietly that he needs to tell them, but George isn't having it until his dad wants to know what's up with their whispering. Because, you know, two doctors whispering about your test results isn't obvious or disturbing. They all stare at George, who finally offers, "The biopsy results were abnormal." When his dad asks if this is bad, George freezes and can't even look at him. He stares at Cristina, and it's left to her to tell O'Malley Senior that he has cancer in his esophagus, which has spread to his stomach, and that he'll need surgery, chemo, and radiation. They all stare at her, slack-jawed; George stares at the wall.
Meredith finds George and Izzie in the stairwell, and George explains that his dad has Stage 3 static cancer and they'll operate this week. He begins to say something about his brothers, but before he can voice it he tells them instead that Callie slept with Sloane. When he's not speaking, you can actually hear the sound of his life crashing all around him at once. He can't really form sentences but also stutters out that Burke's maybe not okay, and Cristina had to tell his dad when George couldn't even look at him... basically, George is a giant mess. Izzie assures him, "Nobody gets it right with their own family." Meredith concurs, "I certainly don't." Izzie takes the moment of silence to ask, "Callie slept with Sloane?" George huffs, "I don't get you people." I thought he meant that he doesn't get how his best friend can be callous enough to make a statement like that right now, but it turns out he means women altogether. "Us with the boobs?" Meredith asks. "We make a lot of bad decisions."
Alex is checking on Frank by himself and as he does, he comments that he can't believe Frank would do this. Frank just counters by asking if Alex has done anything crazy for a woman. He also asks about Izzie, saying, "Frank can sense the vibe... " Alex cuts him off, and Frank manages to guess what's going on. When Alex tells him it's more complicated than Izzie leaving him for someone else, Frank tells him, "Uncomplicate it, man." He tells Alex to go for a grand gesture. "Trust Frank. Frank knows."