Izzie wants a real Thanksgiving dinner, and she wants it done right, damn it! Unfortunately, none of her friends will help her -- Mere has volunteered to work, George is hauled off by his kinfolk for their traditional Thanksgiving Day turkey-shootin' extravaganza, and Alex won't return her calls. Her savior soon arrives in the form of Burke, who turns out to be a great cook (his mother owns a restaurant in Alabama!), and guides Izzie through turkey surgery. Cristina mostly sits around and complains that there's no booze in the house, then makes her escape to the hospital. Meredith gets McDreamy -- who is also supposed to be home having sex with his wife for the first time since their split -- involved in the case of a man who's been in a vegetative state for seventeen years. The man wakes up, sees that his family has moved on, is sad, then dies in surgery. Whoops! George finally shoots himself a turkey, but before he can escape from his good ol' boy daddy and brothers, one of the brothers accidentally shoots Daddy in the ass. George is then forced to root around in his own father's posterior to retrieve the bullet. They bond, as you do. Meanwhile, Bailey is tormented by a visiting hotshot doctor, so she hatches a little plan to take him down a few notches...which works so beautifully there aren't words to describe it. Well, there are two: Happy Thanksgiving!
We open at Meredith's, on Thanksgiving morning. Meredith breaks the news to Izzie that she won't be able to help her with dinner, because she's going in to work. Izzie starts whining about it, but is interrupted by the doorbell. Mere opens it to find three strapping men in outdoorsy clothes. The big one asks if this is where "Georgie" lives. As soon as they have confirmed that this is, indeed, where Georgie lives, they shove Meredith out of the way, head up the stairs, and start chanting, "O'Malley! O'Malley! O! Mall! Ey!" Izzie: "Should I call the police?" Meredith seizes the commotion as her chance to escape, and runs off to work. Izzie yells after her that she better be back for dinner at six, and she means it.
George is in bed doing a funny little countdown, and as soon as he gets to "one," the door flies open. "O'MALLEY! Happy THANKSGIVIIIIIING!" Poor George.
Over on the ferryboat, Addison tells McDreamy that she was thinking they could...have sex tonight. McDreamy chokes on his coffee, then tosses his beautiful hair and regains his composure. Addison just thought it would be a good idea, because they haven't done it since all the cheating and the Meredith and whatnot. She says she has the day off, but McDreamy says he has to check on a few patients. Addison feels that they should just "rip the stitches" and get it over with. Well, that makes it sound extra-hot. McDreamy adds, "No anesthesia?" Addison says that's right, and asks what he thinks. He thinks this stupid ferry is totally messing up his hair.
Cut to the hospital. Bailey tells Mere that they're working with a temp attending today, so they need to get him oriented. She also thanks Mere for volunteering to come in, saving her from having to choose an intern to torture. Mere says she's happy to be tortured, and doesn't have whole hell of a lot to be thankful for. As they walk through the halls, Bailey tells Mere that too much family time at Thanksgiving makes people depressed, which leads to repressed childhood rage, bitter disputes over the remote control, and way too much alcohol. "People get stupid. People get hurt." Bailey is grinning from ear to ear by now. Mere asks why that's such a good thing. Bailey: "Surgeries, Grey! Lots and lots of surgeries. The stupidity of the human race, Grey. Be thankful for that."
McDreamy finds Webber looking at the board, and tells him he's supposed to be at home. Webber's like, "So are you." Then Burke walks out of surgery gloating about how he just performed the fastest procedure he's ever done. They rib each other over who can't function ten feet away from the hospital, and that they're all leaving very soon. Burke: "Say it like you mean it." Webber insists he knows how to have a life outside the hospital, really, he does! No one believes him.