Izzie, ever supportive and tactful, quietly grills George about if he's happy, not noticing Callie behind her, who answers loudly that they're incredibly happy. Izzie fakes a, "Yay!" and the newlyweds share a kiss. Izzie asks to see the ring, and Callie holds up her hand to show a thin gold band with the tiniest diamond one can see without a magnifying glass. With her fine track record of verbal diarrhea, Izzie pronounces, "Tiny diamonds are great because you know no one will ever try to steal it." Bailey breaks up the pause by realizing that the idle interns are about to cause a ruckus and assigns Alex and Izzie to find some patients and the others to get to the hospital. Quietly and awkwardly, she also offers the couple congratulations. Callie mumbles to George, "We've only been out of our Vegas hotel bubble for six hours, and I don't like it." George assures her that it's fine, because they're married, and he sounds genuinely happy for the first time in eons. She happily agrees and looks at her ring.
George walks out with the Chief, trying to be suave: "So, Chief, we're a couple of married men." Webber has to break it to him that he's actually getting a divorce. It shuts George up, and Webber goes on to say it's life, and then leads him into a room where he explains that the patient -- Marina Wagner -- was in eight months before and had a tumor removed and has since gone through chemo and radiation, sadly noting that he thought she'd beaten it. Her boyfriend comes in just then, asking if it might be food poisoning. The chief looks confused and says that it might be complications from the radiation, which puzzles the boyfriend, who denies that she had cancer. D'oh -- someone's going to have some 'splaining to do. It's not going to be the Chief, who at that moment sees Ellis outside and hurriedly orders George to do some tests and runs out of the room.