Jack's wife, Bella, is seeing a therapist, but she liked Lecter so much (which, frankly, seems impossible) that she wants to see Lecter instead. He assures her that while it's unorthodox to see someone who works with her husband, it's not unethical. Okay, show, whatever. Suspending disbelief!
Will is struggling to get inside the mind of a killer who is being lead around by a brain tumor and goes to Lecter for guidance. Lecter manages to make the conversation about Will and Jack, which causes Will to blurt out, "Are you trying to alienate me from Jack Crawford?" Lecter assures him he's just trying to help, but Will looks uncertain and skeptical. Elsewhere, the killer strikes again, turning a security guard into a high-flying angel... and castrating himself in the process. According to Will, he did it as a way of accepting his fate of impending death. Apparently angels don't have balls. I'll have to ask my clergyman about that. On a side note, this Angel Maker plot is gross, but it is in a nice shout-out to Silence of the Lambs, where Lecter strung up a guard. I think. It's been years since I saw it, but the image of an angel-like figure strung up on Lecter's cage is pretty memorable. Also: SO GROSS. As Will tries to make heads and tails out of the flayed bodies, Jack isn't pleased with his lack of answers and Will ends up snapping at him. Jack hollers back and I guess it was supposed to be a tense moment, but it's hard to create emotional tension out of some Big Words when there's a guy dangling over them on wings made out of the skin of his back.
At the lab, the team has finally ID'd the victims from the hotel. Turns out they were wanted criminals. Same with the security guard. Will realizes that the killer is somehow psychically privy to his victims' CVs and thinks he's doing the Lord's work when he skins them. This gives Will something to think about. Meanwhile, over at Lecter's office, Jack's wife is back in session and we finally find out why she's there. She's not just having a Feminine Mystique meltdown or whining about how her husband isn't giving her what she wants. Instead she has cancer and will die soon and doesn't want to tell her husband. Even Lecter thinks that's a weird plan.
Later, Will wakes up on his roof ready to sleepwalk right off the edge, which isn't a metaphor AT ALL. He returns to Lecter who basically tells him to get a nap or a new job or just accept it.
The FBI has a lead on a suspect. He was in the cancer registry and has a fishing license (which explains the hooks he uses to hang his victims). They don't bother trying to figure out if there's anyone else, they know it's their killer. They pull his estranged wife in for questioning and as she talks about how her husband was pulling away from her and removing himself from the family, Jack suddenly realizes what might be going on with his wife. He starts to tear up as he recognizes his wife's condition, leaving Will to lead the questioning. Will discerns that while the killer was never religious, he did have a near death experience as a child that lead him to believe a guardian angel was watching over him. The fire was at a farm, which is where the team heads next. Sure enough, they find the killer. But he is already dead and has somehow strung himself up, making wings out of his flayed back skin, tying his legs and ascending from the ceiling. How one does that to himself requires a MacGyver level of skill and imagination that I can't comprehend. Back to suspending disbelief! Looking up at the body, Will decides to tell Jack about his feelings. It's too hard for him to look at all the crime scenes and get in all the killers' heads. Jack doesn't buy it and leaves Will in the barn to think about his actions.