House sends the Numbers off to test their theories while he chases down Chase, who's leaving work with Cameron in tow. House threatens to have Chase fired for performing a test for a fired employee. Chase calmly says House is just taking out his frustration with the case on him. If he needs Chase's help, he can ask for it. If he wants to vent, he can find someone else. For her part, Cameron says she likes it when her man sticks up to her other man. She smirks away as 13 and Grumpy rush up and tell House that POTW now has pneumonia that antibiotics aren't helping. The bacterial infection diagnosis idea was wrong. So was scleroderma, as Grumpy says the tests came back negative. House thinks they're looking at cancer.
So does Foreman, who tells New York's version of Cuddy that they've ruled out a fungal cause and everything points to anaplastic large-cell lymphoma. NYCuddy says it could also be an infection, which is a lot easier to treat. But Foreman says that the cancer is such an aggressive form that if they wait to confirm his diagnosis, it'll be too late. But if Foreman's wrong and it is an infection, NYCuddy points out, the cancer treatment will have destroyed her immune system. "I know you have some experience with that," NYCuddy says. She thinks he's trying to atone for his past mistake with this patient, and could be making the same mistake twice. Foreman doesn't think he was wrong about the cancer, but agrees to follow the order and administer the antibiotics.
Back in NJ, Original Recipe Cuddy confronts House just outside the elevator, demanding to know why he ordered eye-removal surgery on his patient. House says that's what his unproven cancer diagnosis says is the source of POTW's possible cancer. Cuddy thinks House should do a biopsy first, but House is so sure he's right that he sees no need to waste time with something as silly as proof. Cuddy's resolve crumbles, and House starts screaming for Wilson to come watch him "cut some cripple's eye out." Wilson immediately appears on the scene, probably expecting that this is part of another fight over PPTH's limited handicapped parking spaces. "Good times," he says.
Not so much, since Wilson has to now explain to POTW that he has skin cancer in his eye, which they're going to be taking away now. POTW doesn't see much point in treating the cancer, now that's it's clearly spread all over his body. Wilson says there's a chance that if they remove the primary source of the cancer and give him three rounds of chemo, he'll live. For a few months. House tells him to sign the consent, but POTW is weighing his options. Either he dies now, or he dies after a few months of puking and pain, confined to a hospital bed. Honestly, he'd rather die now. "I've been trapped in this useless body long enough," he says. "It'd be nice to finally get out." And when you think about the fact that the co-writer of this episode knows someone with SMA, that had to be an almost impossible line to write. House doesn't have time for poignant moments, though, as he has to make fun of POTW's belief that he'll sprout wings and go flying up to heaven. Wilson angrily tells him to shut up, and they take it outside.
Wilson asks House why he can't even let a dying man find some comfort in his beliefs. "His beliefs are stupid!" House singsongs. And really, does Wilson expect anything better out of House at this point? Doesn't he know him at all by now? Apparently not, as he asks House why it bothers him to let a guy with days or even mere hours left to live think there's something better on the horizon. "He shouldn't be making a decision based on a lie. Misery's better than nothing," House says. Well, the thing is, believing in the afterlife isn't like, say, believing in Santa Claus. The people who tell you it exists also believe it exists themselves. If they don't think they're lying, then is it really a lie? At times like this, I wish I took a philosophy class in college. Wilson says House doesn't know if there is an afterlife or not since he hasn't been there. Well, except for those two times.