No one except Foreman gets any sleep this episode, which takes place over the course of one night of terrible ideas from our cast of characters. First off, Taub finds out that Ruby, the nurse's aide he's been dating, is pregnant. She wants to have the baby. He doesn't. Foreman tries to console him with a trip to a strip club, but that goes poorly when Taub notices an asymmetrical mole on his stripper and keeps trying to touch it, getting him kicked out of the club. He insists on sticking around until closing time to try to talk to the stripper about her mole again, but she is freaked out to see him waiting for her and pulls a gun on him. She ends up driving away without shooting Taub, who realizes when his life flashes before his eyes that it would be nice to leave a kid behind in this world after all and tells Ruby he wants her to keep the baby too.
Meanwhile, Hadley gets a visit from a prison friend who was stabbed while running away from the cops. She needs medical attention, but doesn't want to go to a hospital for fear that she'll be arrested. She asks Hadley to tend to her wound instead, but when she loses a pulse and blood pressure in one of her arms, Hadley needs Chase to come over with a portable ultrasound to figure out what's wrong. When the friend, Darrien, starts to hallucinate, Chase insists that Hadley has to break her promise to Darrien and take her to a hospital. Hadley still refuses, but Chase is much stronger than she is. He's also right -- it turns out that Darrien had parasites in her liver that were released into her bloodstream when she was stabbed, thus causing all the complications. Darrien's life is saved, but her trip to the hospital is going to be followed by a trip to jail. She is not happy with Hadley for this, but Hadley knows she did the right thing. And she and Chase find out that the other one killed someone for what they thought were the right reasons, even if it did make them both feel really bad about it.
Finally, there's House. He finds out that all the rats in the muscle-re-growing drug trial died after getting a bunch of tumors, which means the drug is not a success after all and it's a good thing it was never given to any humans. Oops! It was given to one human: House, who runs off to scan his leg for any new growths and is not pleased to find three tumor-looking things in his leg. They need to be removed, so he decides to go ahead and do it himself. In his bathtub. Yeah. He manages to remove one of the tumors, but then he's in too much pain and his system is too traumatized for him to be able to continue. He calls Wilson and the Cottages for help, but they're otherwise occupied, leaving one person left in his phonebook: Cuddy. She dutifully comes to his apartment with Rachel in tow and brings him to the hospital so a surgeon can properly finish what House started. He asks/begs her to be in the operating room with them to make sure they don't chop away any more of his muscle than necessary and especially not his entire leg, saying he trusts her more than any surgeon. She agrees, and House wakes up from the surgery with his leg intact and a lecture from Wilson waiting for him, as well as a note from Rachel, who misses his terrible paternal influence.
A desperate, bleeding woman breaks into a car and hotwires it to life. She speeds through traffic, but has a hard time driving safely due to being on the verge of passing out from blood loss. Finally, she drives into some newspaper boxes on the Fox city street backlot set, gets out of the car, and staggers into an apartment building that apparently doesn't lock its front door. She knocks on the door of Apartment 3, and Hadley answers. Oh, good. I was hoping for another Hadley-centric episode. They're so rare these days!
But Hadley's friend, Darrien, is not at PPTH when the credits end like your typical Patient of the Week, but still in Hadley's apartment. She doesn't want to go to the hospital because the police will find her there and send her back to the jail where she and Hadley met for hanging out with convicted felons. Wait -- shouldn't Hadley also not be allowed near convicted felons? Like... Darrien? Whatever. Hadley doesn't seem too worried about it. Darrien thinks Hadley can just fix her up, but Hadley says it's much more complicated than that, and if Darrien were to die in Hadley's apartment, Hadley would be charged with manslaughter. That would be kind of funny, though, if Hadley managed to be charged with manslaughter of a friend just a few months after getting out of jail for killing her own brother. Darrien would rather leave Hadley's apartment and die in an alley than go to the hospital, leaving Hadley with no choice but to agree to help her in her own home. She promises Darrien that she won't take her to the hospital.
House is relaxing at home, and he has company: one of his prostitutes, who is considerate enough of her client to refuse to agree to a Kama Sutra position he's proposing because she knows House's bad leg won't be able to do it. House says she doesn't need to worry about that, as he is taking an "experimental medicine" that regrew his leg muscle. He tries to prove his newfound strength to her by lifting up some huge, heavy guitar amps. He's successful in his efforts for a few seconds before one of the amps topples over and falls through his glass coffee table. His special rat medicine was also on that table, just sitting out in the open in a little dish, and so spills all over the floor. House will have to get more, which he'd rather go out and do than spend time with the prostitute. I guess the unsuccessful guitar-amp-lifting killed the mood.