House calls Wilson again. The poker table has turned for Wilson, and he is now faring quite poorly against Cuddy. But now that House wants Wilson to do well (and therefore keep him and Cuddy playing), he gives Wilson some winning advice after expertly figuring out that Wilson is holding a middle pair by the pitch of Wilson's voice. House also knows that Wilson's hand beats Cuddy based on how she's drinking her seltzer, and advises Wilson to go all in. He does. Cuddy folds. House hangs up. Playing poker with House is a lot like that SNL sketch where everyone gives Sherlock Holmes presents and he figures out what's in all of them without having to open them.
While Chase and Foreman dose Ian with every drug that will prevent liver failure, House watches from outside. Obsession! Chase comes out and tells him that the treatment seems to be working, although Ian's platelets are dropping. House says that this is a good thing, because it tells them something Ester's case did not. Suddenly, Ian goes into respiratory distress. House leaves to write some more on his Whiteboard.
Thanks to his treatment, Ian has ended up at the same place Ester did in an even shorter time, having skipped over the liver and spleen symptoms and gone right to the respiratory failure. That was Ester's last stop before she died. Now that the Whiteboard is useless to him, House dramatically knocks it to the ground, taking out a lamp and everything. It's a good thing House doesn't lose that many patients, or else PPTH would be spending half of its money on replacement lighting for his office instead of windows.
Ian is still dying. His parents are still bland. The Whiteboard has been lifted back up. House wants to know which one of their treatments accelerated the disease's progress. They know that interferon can affect leukemia, which gives House an excuse to call Wilson.
Wilson's still at the poker table playing the longest heads up game ever, and Cuddy is sick of House calling in and ruining her game. She says as much, and House says this means that she's vulnerable and that Wilson should go all in. Wilson responds that "the party is over in less than three hours." Cuddy picks up on this right away as coded poker talk that Wilson either has three of a kind or he's holding threes. She bets five hundred on that, and House impatiently orders Wilson to go all in or else he'll tell everyone in PPTH that Wilson wears toenail polish. I doubt that anyone there would listen to House or really care that much about Wilson's toe care regimen, peculiar though it is, but Wilson is sufficiently frightened by the threat to go all in immediately. Cuddy calls and shows him her trip nines, confident that she has Wilson beat. Wilson obnoxiously shows that he doesn't have threes of any kind at all: he has a straight. That conspicuous three hours mention was his clever way of throwing Cuddy off the track. Wilson's back in it to win it for about three seconds before House tells him that if he doesn't get his oncologist butt up there, a six-year-old will die.