Recent lottery winner Cyrus comes to PPTH after his leg becomes paralyzed in the middle of his mission to be reunited with his long-lost love now that he's super-rich. Fortunately for him, she shows up at PPTH shortly after he's admitted and seemingly wants nothing to do with his money. Unfortunately for him, he ends up having not one, but three tumors that are three different types of cancer. Oh, and that woman was actually a fake sent by Cyrus's cousin and best friend to try to get more of Cyrus's money even though Cyrus was willing to give the guy ten million dollars just for being his friend. House decides that Cyrus must have something else wrong with him to cause him to develop these tumors, and so pumps Cyrus full of tumor-growing drugs in the hopes of finding out what as quickly as possible. Not only does that not cause any new tumors to form, but it also actually shrinks the existing ones. Ultimately, House figures out that Cyrus's problems are all due to another tumor -- a teratoma, best known to me as those horrible, horrible tumors that can grow hair and teeth. Cyrus's teratoma does not have hair and teeth, but it is full of brain cells, which have somehow leaked into Cyrus's bloodstream, causing his immune system to attack them and also the cells in his actual brain for good measure. This also somehow caused all those cancers, but Cyrus will be fine once the teratoma is removed. And he has something to live for, as his real long-lost love finally shows up at PPTH.
While all this is going on, we also have the B, C and D plots. Hadley is being negative and miserable and House is determined to find out why, only to realize that it might have something to do with the fact that her nearly-over life totally sucks. Chase tries to get Foreman to de-stress at work, claiming that he's been much happier ever since he stopped having sex with tons of girls, but Foreman can't de-stress and it turns out that Chase can't stop having sex with tons of girls, either. And Cuddy is being sued by her own mother, who is slow to recover from her hip replacement replacement operation and wants PPTH to pay for it with several thousand dollars and most likely the revocation of Cuddy and House's medical licenses. In the end, it turns out that Murphy Brown doesn't really want to sue her daughter, but was hoping that Cuddy and House would unite against her and get back together again. It doesn't work.
Cheery music plays as Donal Logue, bouquet in hand, paces nervously in front of a small house before ringing the doorbell. Jennifer Williams answers, and Donal introduces himself as Cyrus Harry, who spent a "long weekend at the Jersey Shore" 23 years ago with a woman named Jennifer Williams. He's trying to find her again. Clearly, that weekend wasn't very memorable, since Cyrus can't even tell if the woman at the door is the right Jennifer Williams or not. I'm going to go with "not," since this one slams the door in his face. He crosses her name off the list and heads back to his limo, telling his chauffeur they're going to Philadelphia and the next Jennifer Williams. The chauffeur grumbles at this, even though he's apparently making six figures at this job, thanks to his boss being his very generous cousin, and says he doesn't understand why Cyrus is wasting so much time on a memory of a woman when he has enough money to get plenty of real ones. Cousin Phil starts to apologize for being cranky, but Cyrus isn't listening because he suddenly can't move his leg.
House passes out the new patient file, saying that something seems to be wrong with Cyrus's brain, but all tests have come back normal. Taub zeroes in on the important part of Cyrus's medical history: he just won $42 million in the lottery after a lifetime of eking out a living as a refrigerator repairman. Taub thinks Cyrus is really lucky, but House figures that Cyrus will blow the money just like other lottery winners he's read about, saying money can't buy happiness and Cyrus was clearly miserable enough before the win to buy lottery tickets in the first place. "Our level of happiness is set. It's in our DNA," Hadley agrees. "It's like there's two of me," House notes. True. Why have her back on the show at all, then? One House is plenty. Cuddy suddenly enters the room and informs House that her mother is threatening to sue PPTH, saying their poor care slowed her recovery time. House cheerfully says that's fantastic, as he now gets to still deal with Cuddy's mother while also not getting to have sex with Cuddy. While he does that, he sends Chase and Foreman to check out Cyrus's workshop and Taub and Hadley to check out Cyrus.
House takes some Vicodin, saying they are necessary to prevent the pain in his ass he's expecting. Cuddy ignores him and explains that her mother is recovering slowly from her hip replacement and having trouble moving, so Cuddy offered to let her move in with her. This caused a huge fight for some reason, and now Murphy Brown wants to sue PPTH, which could lead to the revelation of all the not-quite-medically-ethical stuff House and Cuddy did to her. Which means they could both get in serious trouble, up to and including having their medical licenses taken away. Is that really such a threat? Hadley went to jail for killing her own brother and she got her medical license back in three seconds. Murphy Brown wants to discuss a settlement, but insists on meeting with both Cuddy and House. Which means House will have to play nice in front of Cuddy's mother while Cuddy tries to talk her mother out of ruining her own daughter's career. Wow, this seems really complicated. I guess they should have just let Murphy die after all. House has no intention of going to any meetings.