Chase and Cameron are suited up and performing the surgery, which Giles gets to be awake and aware for because it involves his brain. Chase will be doing the surgical aspect of the surgery, while Cameron will be asking the patient how he feels and expositing technical details while the Magic School Bus Cam shows us a thin wire snaking through Giles's brain, grabbing the clot, and pulling it free. I bet Chase is good at those grabby-arm arcade games, too. Cameron informs Giles that the surgery is over and successful. Giles is disappointed. He was really hoping he'd be dead by now, goddammit.

Foreman's in House's office, apologizing for the earlier humility remark. House says he doesn't care for apologies. Foreman says he was really rude. Again, House doesn't care. He says that Dr. Smiley's much-lauded humility is fake. Real humility means self-doubt, so it's only important for people who are wrong a lot. Foreman points out that House has been wrong about everything in this case, and then gets all apologetic-looking for stepping out of line like that. But House loves it when he gets as good as he gives, so he just smiles and says that self-doubt doesn't help when you're right. And then his beeper goes off, and they're off.

House and Foreman walk to Giles's room, where Dr. Smiley congratulates "Greg(g)" on a surgery well done. Giles just woke up and his arm is better. Surprisingly not into giving himself a pat on the back today, House just points out the presence of a phone in Giles's room and asks that the next time they have something to tell him, they use that so he doesn't have to leave his chair. Awkward blocking ensues as House goes out of his way to give Giles a pat on the leg as he leaves. Giles says he just felt that. We go to commercial before House can yell at him for ignoring his previous request about phone communication.

Chase and Cameron follow House into the meeting room. He says that Giles has feeling in his calves, but that they have no idea why.

Meanwhile, Dr. Smiley tells Foreman he's sure it's the experimental ALS drugs he prescribed that caused Giles's condition to improve.

House says that the only way to figure out what's helping Giles is to take him off everything, and then test each medication one at a time and see which one makes him better. It's preferable to keeping him on all the medications, most of which can be toxic if given unnecessarily.