While Chase and Martha prepare Danny for the X-ray, they inform him that they know he was a heroin user in the past. Danny admits that he was, but claims that he's been clean for months now since he clinically died after an overdose. He then went to rehab, which is apparently available to homeless people with no money, and was determined to get clean because he thought surviving the overdose meant God gave him a second chance and he wanted his life to mean something. Martha is positively charmed when he says he's hoping to turn things around and become a doctor. He says he was once in a pre-med program in college, so it's not entirely out of the realm of possibility. Martha interrupts him to call Chase over and check out something strange on the X-ray.

The entire team head into the lightbox room to check out the X-rays of Danny's abdomen, which show thirteen masses in his colon. They don't know what they could be, as they look nothing like tumors and tests for parasites came back negative. House comments that it's surprising that a homeless junkie wouldn't have any parasites, but Chase and Martha inform him that Danny is no longer using drugs and planning on getting his life together so he won't be homeless anymore, either. "He wants to be a doctor," Martha gushes. Taub rolls his eyes at Martha's naïveté, saying Danny is just telling Martha what he thinks she wants to hear. House, of course, knows that no drug addict stays clean for long, and says so while taking a few Vicodins just to prove his point. Martha softly asks if he could not take those in front of her. She did say please, but House has no intention of obliging her, of course. House tells the Cottages to treat Danny for a possible fungal infection and stick a scope up his ass to get a good look at those masses.

Taub gets the ass-scoping duty. He takes this time to talk to Foreman about House's wedding, suggesting that they boycott it "on principal." Foreman says he feels obligated to go since Dominica gave him a foot massage and he's in the wedding party, along with Chase. Now Taub is indignant not to be invited to be part of House's wedding party. Foreman doesn't know why Taub cares, since he was just planning on not going at all. "I still have feelings," Taub sulks. And then they catch a glimpse of Danny's colon masses.