With that, Kumar enters and says that the heavy metal treatment isn't working. Not even the Megadeth? Jimmy really is punk rock to the core. Or not, as Kumar adds that Jimmy volunteers at a home for abandoned children. House yells at Kumar for telling him something that isn't "medically relevant," even though it's tiny, inconsequential-seeming details like this that always solve the case. Usually, we get those details earlier in the show so it doesn't look quite so obvious, though. "Stop playing games and do your job," Wilson orders, although I'm not exactly sure what game he thinks House is playing right now other than the game the writers are playing called "Who Can Fit The Episode Title In Their Episode The Most, No Matter How Clumsily And Nonsensically?" It's like pin-the-tail on the donkey, but with words!
Back in the classroom, House says he's going to try firing PS and CTB to see what they can come up with. Then he fires Kumar and Thirteen again just for the hell of it. I don't think anyone takes House's firings seriously anymore. They don't come up with anything, so House says he'll just get a kid to tell Jimmy he's dying, since that's the only people he seems to be able to relate to. It's an awkward line that comes out of nowhere, but is necessary to the plot, as it gives House an idea. He asks Kumar about those abandoned kids. "Is it medically relevant?" Kumar spits back at him, not knowing when the right time for a retort is.
House reports to Cuddy's office with all of the Numbers in tow. He lines them up in front of her desk and asks Cuddy if he can do a brain biopsy on Jimmy. Cuddy asks if he's talking about the patient who almost died during unnecessary open-heart surgery. House eagerly nods "yes." Cuddy just as eagerly shakes her head "no," then asks why he's brought the Numbers to her. He says all four of them helped him solve the case and he wants her to know it and feel guilty about ordering him to fire two of them. So, how did they help House? Well, CTB thinks Jimmy is a loser. Thirteen thinks he's a winner with a few problems. PS thinks he needs to grow up. And Kumar thinks it's an autoimmune disorder. Individually, they are wrong, but together they helped House figure out the right answer -- measles. He got them from the children he volunteers for, and any vaccinations Jimmy had against measles wore off from years of drug abuse messing with his immune system, which also overreacted to the virus and caused some of his other symptoms. So CTB was right that it was drug-related, Thirteen was right that Jimmy had at least one redeeming factor with his volunteer work, PS was right that he was childish and expressed that by hanging out with measles-carrying abandoned children, and Kumar was right that it had an autoimmune component. But Cuddy won't let House do a brain biopsy unless Jimmy displays some neurological symptoms. CTB pipes up that she noticed Jimmy kept swallowing, which could indicate a partial seizure. She even demonstrates it to comedic effect. To get rid of them all, Cuddy tells House that if he can induce a seizure, she'll let him do the biopsy.