Back in the office, the Cottages report that Jessica's necrosis is getting worse. Cameron "I told you so"s that it's probably because they're treating Jessica for the wrong thing, but since she still doesn't have an alternate explanation, House ignores her. Wilson, who is suddenly there, says that if the necrosis doesn't start to get better by the end of the day, they'll have to remove it before it spreads and kills her. Why is he telling them this news? Did Vogler fire the entire dermatology department?
Foreman and Wilson tell Mom that if the necrosis doesn't start getting better in a few hours, they have to do some amputatin'. A radical mastectomy before poor Jessica's breasts even got a chance to really exist.
House looks over some nasty pictures of necrosis, which may or may not be his screensaver, until Cameron enters, demanding to talk. House immediately goes for his pills as Cameron asks him if he is pursuing this diagnosis-based-on-her-mistake thing because he's just looking for a chance to fire her because he "can't deal with [his] feelings for [her]." House: "[pause, exasperated sigh] I believe that you were the only one to express feelings." That's true. And grow up, Cameron. And, of course, shut up, Cameron. Don't you dare be all sassy and cool this episode and then ruin it with this boss-crush personal bullshit emotional woman crap! Cameron takes a few cheap shots at House's lack of friends, then volunteers to quit to make things easier for everyone. House says that sounds fine. I agree!
Tumor Lady is back, and House shows off those pictures of her kids, including one with blue eyes, and the other with green eyes. Since Tumor Lady and her husband both have brown eyes (and House apparently doesn't think that anyone in the world wears color contacts), that would mean that at least two of their children don't belong to the husband. Shouldn't this B-plot have taken place a few episodes back? House asks Tumor Lady if she doesn't want to have the surgery because she's afraid that all the other men she's sleeping with won't find her attractive anymore. If that's the case, Tumor Lady will be happy to know that men will have sex with anyone, including skinny ladies with hot surgical scars. Tumor Lady says she'll go through with the surgery. That was just stupid.