After the break, the Cottages inform House that their patient is probably an alcoholic. Hadley, now 100% in the role of Cameron, cares only about the ties House keeps testing out in front a mirror. House has two to choose from, and both, he claims, will make him look "adorably non-threatening" at Thanksgiving. One of them has cartoon turkeys on it. That one is awesome. And yet, the Cottages choose the ugly brown tie with red Xs (or are they supposed to be turkey feathers? God damn my non-HDTV) on it. Chase thinks James has liver failure from the alcohol, but House says alcoholism is a "pedestrian" addiction for a super-genius. The Cottages disagree, to the point where they're ready to hold off on the liver biopsy until after Thanksgiving because they're that sure of the results. House doesn't think so -- he assigns Taub and Hadley to do the liver biopsy on the holiday just in case the results that come back are not what they expect them to be. That sucks for Taub and Hadley, but it's not unwise, since the results are never what they expect on this show. As for Chase and Foreman who have no one to spend time with on Thanksgiving, they get the day off. So that should be fun for them.
Taub and Hadly prepare to biopsy James' liver. His wife gets to hang out in the room with them, which means she can hear what James is saying. So, of course, he denies being an alcoholic. He does say that he drinks, but "not a lot." The fact that he drinks at all is a surprise to Dara, who is not thrilled to hear that he drinks a shot of vodka after work every night. Hadley says the fact that James does this in secret shows that he has something to hide. "My liver is fine!" James says. Well it won't be if he keeps squirming around while Taub is in there with the biopsy needle.
Ew, harmonica music. While Cuddy, Lucas, and various others sit around a table with food and fun, House pulls up outside Cuddy's sister's house, which is a pretty bleak place since they digitally removed some of the color from the shot. He walks up to the house (which is huge -- Cuddy's sister is LOADED!) and knocks on the door. Inside, Cuddy looks back. But not at the front door -- at a clock. The door is answered by some woman who is not Cuddy's sister but a house-sitter. She explains that Cuddy's sister is in Hawaii this week. The nice Thanksgiving feast Cuddy and Lucas are attending is actually at Cuddy's house, and she sent House on a three-hour-long wild goose chase to her sister's to make sure he wouldn't stop by. While she and Lucas and their guests toast to a happy Thanksgiving, House is in the cold, bleak house of Julia with just the house-sitter and her offer of a turkey sandwich to keep him company. That's mean, Cuddy. I guess she figured it was the only way to prevent him from doing something to ruin her Thanksgiving, but still. At least she has the decency to sort of look guilty about it.