Foreman and Cameron inform House that both patients are almost dead, so it looks like they were wrong about that particular poisoning theory, and the treatment they gave them, of course, made everything worse. House uses the fact that the kids' hearts are crapping out so much more quickly than their rest of their bodies to conclude that they ingested the poison through their skin sometime between when they woke up and before they boarded the bus. Cameron and Foreman will be going to both patients' houses to see if they have any skin products, such as acne cream or deodorant, in common. And if Cameron could bring back some more of Margo's tomato sauce, that'd be great.
House limps out of his office and into Grandma Sex, who says she snuck out of her house to see her boyfriend without her son and his stepfather-resentment issues around to get between them. Perhaps House could take the son out on a fishing trip or off to chop wood so he and House could have a chance to bond? House tells Grandma Sex that he's very sorry, but that he knows from experience that syphilitic brain damage does not a basis for a good relationship make. Plus, he finds it difficult to chop wood with a bum leg. Grandma Sex asks if it's just the syphilis that has given her all these new "feelings" (in all sense of the word, I'd say). House says it is. Grandma Sex says, in that case, she'd like to keep her syphilis, and returns the prescription to House. She'd rather die feeling sexy and loving Ashton from afar than playing canasta all day long or whatever it is that the unsexy old folks do to live out the rest of their days. House actually smiles, then says that he has some great news: Grandma Sex's brain damage is irreversible! The drugs will only keep it from getting worse and causing the slightly-less-pleasant brain damage we all hear so much about. Grandma Sex is "doomed to feeling good for the rest of [her] life," House says with a smile, probably because he's high on the Vic, which will be making him feel good for the rest of his life as well. A thrilled Grandma Sex goes to give House a hug, but he asks her to respect the boundaries of the doctor-patient relationship. "When I stop being contagious, I'll come back for a checkup," Grandma Sex says with a wink. Well, she's got self-confidence, I'll give her that. House chuckles as he watches her go, and then limps off to fire the person who keeps telling his patients where his office is.