OOPS! The cancer vaccine kicked Frankie's immune system into overdrive, and she now has a fever of 104. The team throw her a few ice packs before heading to Cuddy's office to give her something to do this week. Cuddy says they'll have to stop giving Frankie the vaccine, because it's better for her to die later from the cancer rather than sooner from the cancer vaccine. Meanwhile, House finds it odd that when Hadley administered one of the vaccine injections, she had to wake Frankie up to do it. "Who can sleep in a hospital?" he wonders. Well, House can, for one. And does. Often. Also, patients. I used to work in a hospital and the patients were always sleeping. Mostly because they were old and tired, but also because there was nothing else to do. Chase doesn't see anything unusual about it, pointing out that Frankie is a "night owl," as she told him when he ran that late-night test on her earlier. House takes over Cuddy's laptop and checks out Frankie's blog for the first time, noting that while her current posts were made in the early hours of the morning, six months ago most of her posts were during the day. He thinks the day-night reversal is a symptom of liver disease, which then rules out lymphoma. I'm sorry, but I think that cancer cells in a burst appendix are much better evidence than blog time stamps. For all we know, she switched her schedule because it's 12 hours ahead in Singapore, so posting at 2:30 and 4 am means that her devoted, kidney-gifting fan can read the latest Frankie post at work. House says they could have made a mistake and the abnormal cells weren't cancer after all. "Biopsy her liver," he orders. Wow, good thing they didn't treat her with chemo after all, since she apparently didn't really have cancer. I'm sure a hospital with a better oncology department would have realized that. The Cottages leave, and House takes a second to flirt with Cuddy as if they don't now have a history that makes this incredibly awkward.
Chase and Foreman inform Frankie that they were totally wrong about the lymphoma. "You said my appendix was full of cancer cells," Frankie says, confused. Foreman says they thought they were, but now they think they're just a "granulomatous build up from some unknown cause." So basically, once again, they are clueless. All they know is that Frankie is still dying, but now at a much faster pace -- if they can't figure out why her liver is failing, she'll be dead in three or four days. Foreman and Taub leave Frankie sobbing in Taylor's arms.