House and the Cottages go over Jeff's chest x-ray. They don't see any bleeds, meaning that Chase did his job correctly, and that Jeff must have cancer by default. But then Wilson walks in and informs them that the biopsy was negative for cancer, too, although it shows that Jeff has pure red cell aplasia, a bone marrow disorder. It comes in two varieties: chronic, and acute. They can rule out chronic, since Jeff's symptoms came on too fast, leaving them with the acute form -- which is caused by EPO. So Jeff was taking EPO after all, and lying about it while being truthful about everything else, which House finds odd but no one else thinks is relevant.

House, Wilson, and the Cottages are interrupted by the arrival of Cuddy, Stacy, and Ominous Music. "You've got a leek," Cuddy says. Oh, good! I find they taste best in a soup with potatoes. Oh, she meant "leak." As in a "leak to the press about Jeff's possible cancer diagnosis." Wilson and Cameron exchange glances. Stacy says she'll be looking at everyone's office and cell-phone records, which Foreman protests she has no right to do. Way to violate everyone's legal rights to protect someone's medical ones, Stacy. "How am I supposed to practice medicine with a lawyer sitting on my shoulder?" House asks Cuddy. "Responsibly," Cuddy replies, looking sad and defeated. Aw, Cuddy always gets so sad when something happens that makes her hospital look bad. She's sad a lot. Wilson starts to call Cameron out, and she immediately protests her innocence. No one pays any attention to their significant exchange, and Cuddy says that Jeff is threatening to sue the hospital. House -- who was paying attention to Cameron and Wilson after all -- says that it doesn't make sense for Cameron to leak the cancer story, which makes Jeff look good and doesn't reveal his cheating ways. Who would benefit from that leak? "He's on EPO," House determines.

House marches into Jeff's room and removes his breathing tube, saying he doesn't have time to watch the guy write his answers out. Way to follow through on your promise to make sure House doesn't violate any medical ethics, there, Stacy. House gives Jeff an oxygen mask and tells him that he has acute PRCA, which is caused by EPO. House removes Jeff's mask, and Jeff denies using EPO. House doesn't believe him. The manager, distraught, agrees with Jeff. House wonders if Manager has been giving Jeff any secret injections, and she tells him to give Jeff a drug test if he wants, but House points out that EPO is undetectable after six hours. Something that is detectable, however, are cell-phone calls. House wonders if Manager has a few calls to the newspaper that reported Jeff's cancer story on her outgoing list. He reaches for it to check, but she grabs it away from him, which is enough to out her. She admits to Jeff that she did leak the story, figuring cancer would look a lot better for Jeff's image and both of their careers than his doing something doping-related would. House wonders if the manager's unethical need to advance her career extended to injecting Jeff with EPO without his knowledge. As someone who does plenty of unethical things behind people's back to advance his own career, House should know all about that. Manager swears she didn't do it. House asks Jeff whether he really believes her over a doctor. Jeff takes the oxygen mask off, looks at Manager, and fires her. She's absolutely crushed as she collects her things and tells House that if he's basing his entire diagnosis on her slipping Jeff EPO, then Jeff will die.