House marches into Jeff's room and removes his breathing tube, saying he doesn't have time to watch the guy write his answers out. Way to follow through on your promise to make sure House doesn't violate any medical ethics, there, Stacy. House gives Jeff an oxygen mask and tells him that he has acute PRCA, which is caused by EPO. House removes Jeff's mask, and Jeff denies using EPO. House doesn't believe him. The manager, distraught, agrees with Jeff. House wonders if Manager has been giving Jeff any secret injections, and she tells him to give Jeff a drug test if he wants, but House points out that EPO is undetectable after six hours. Something that is detectable, however, are cell-phone calls. House wonders if Manager has a few calls to the newspaper that reported Jeff's cancer story on her outgoing list. He reaches for it to check, but she grabs it away from him, which is enough to out her. She admits to Jeff that she did leak the story, figuring cancer would look a lot better for Jeff's image and both of their careers than his doing something doping-related would. House wonders if the manager's unethical need to advance her career extended to injecting Jeff with EPO without his knowledge. As someone who does plenty of unethical things behind people's back to advance his own career, House should know all about that. Manager swears she didn't do it. House asks Jeff whether he really believes her over a doctor. Jeff takes the oxygen mask off, looks at Manager, and fires her. She's absolutely crushed as she collects her things and tells House that if he's basing his entire diagnosis on her slipping Jeff EPO, then Jeff will die.
Foreman has been assigned to guard Jeff, for some reason. He tells Jeff that the prednisone they've been giving him for the EPO PRCA seems to improving Jeff's condition. Then Jeff's breathing gets ragged and his monitors go off.
The next morning, Foreman tells the crew that the prednisone is not, in fact, making Jeff better. In fact, he's getting worse. His red count is even lower than before. Cameron is very upset that it's starting to look like Jeff's ailments probably weren't caused by EPO, basing her medical opinion that EPO was the perfect answer on the fact that it meant Jeff's lying and cheating were coming back to haunt him. House informs Cameron that the world isn't fair. Case in point: Jeff's manager getting fired for no reason. Well, except for the fact that she leaked that story to the press behind Jeff's back. Foreman says that Jeff has been doing slightly better since getting a blood transfusion. And then House knows the answer. "Go forth and scan his neck," he orders.