After the break, Hadley reports that the effusion has been drained and Jackson's heart is okay again. But heart involvement rules out all conditions associated with his genetic mosaicism, so they have to start at square one with the differential. Foreman remembers they're dealing with an evil teenager and suggests drugs. Kumar doesn't think they should give up on the genetic mosaicism being related to Jackson's condition, and can't believe that House is allowing them to do so. "You're completely unfazed!" he says. House takes great offense to this, saying he's half-fazed at the very least. Hadley hasn't gotten any screentime in like three seconds, so she chimes in to suggest that the testosterone Jackson started taking caused some autoimmune disease. That's good enough for House, so he tells the Cottages to start Jackson on steroids for the autoimmune disease and another drug to block the testosterone.
Wilson marches into Cuddy's office and states that she must have slept with House because he's in a good mood. I would be really offended if one of my employees came into my office unannounced and started accusing me of sleeping with another employee, but a truly unfazed Cuddy just says that if she slept with House, she'd be "curled up in a ball weeping in shame." And she isn't, although she is wearing a cleavage-riffic top. Now Wilson is even more concerned, since if House and Cuddy aren't keeping something from him, then House must be keeping something from both him and Cuddy, which always means trouble. Cuddy isn't too worried, though. She says a good mood isn't a cause for crisis, and Wilson should try to take advantage of it by getting back some of the money House owes him. Wilson leaves, and Cuddy looks Concerned.
Hadley explains the situation to Jackson's parents, because she hasn't had enough to do this episode. Mom doesn't like the idea of taking Jackson off of his hormones. "He'll never be a man!" she says; "did we make the wrong choice?" Hadley averts her eyes so as to keep from saying "yes, and I hate you guys." Dad tells Hadley to tell Jackson the testosterone blocker is something else, but Hadley thinks this might be a good opportunity for them to tell their son the truth. Mom points out that Jackson's not exactly healthy right now, and therefore probably not really up to getting some life-shattering news.
OMG -- House is actually doing Clinic duty! Hooray! I missed the Clinic! His patient has pain in one arm and both legs when he puts pressure on them. He demonstrates by poking them with a finger on his one non-painful limb. House grabs the finger and bends it, and the patient cries out in pain.