We open on a plane. A girl, Leona (not Helmsley, although that would have been a lot more fun than this episode ended up being), listens to some music on her headphones and remarks to her neighbor, played by a haggard-looking D.B. Sweeney, that she was at the studio when her grandfather recorded the piece. This makes her sad, and she reveals to us that D.B. is actually her newly-discovered father and that her mother and grandfather made some "mistakes." Obviously, waiting until D.B.'s The Cutting Edge days were long behind him to tell her who her dad is was one of them. D.B.'s attempts to make Leona feel better are interrupted when the airplane cabin starts flooding. A tidal wave comes gushing out of the cockpit, taking out the flight attendant and several other passengers in a scene that I have to imagine was either really fun or totally hellish to film. As the water heads for Leona, the Magic School Bus Cam shoots inside her chest to her heart, which is beating oddly and has little CGI electricity currents flying around it. New Dad goes running up to his new daughter, who has somehow managed to collapse to the ground even though Economy class barely gives you the room to stretch your legs. Of course, there is no water in the plane at all. This ain't Lost!
As this show is doing more and more, we start in House's apartment. Leg pain is keeping our titular character awake, and he paces around on his gothy black floorboards to alleviate it. When Vicodin doesn't ease the pain, House pulls out his secret stash of morphine and loads up a needle as his answering machine answers his house phone. His outgoing message is the predictable "You've reached a number that has been disconnected and is no longer in service. If you feel that you've reached this recording in error, go with it. Hang up." Cuddy doesn't hang up, but leaves a message telling House to abandon his exciting day-off plans and come in to work. A sixteen-year-old girl came to the ER in cardiogenic shock but without a heart attack to accompany it. That last piece of information is enough for House to put down the needle. For now, anyway.
When he arrives at work, Cuddy brings him up-to-date on the case, and also on the fact that the patient's father claims to know House. "I thought I'd met all your friend," Cuddy says, expertly emphasizing the singular form of that last word. She also has a few medical histories she'd like House to check out, but he seems to ignore this when he sees the patient's father, who runs toward him happily exclaiming "G-man!" House isn't quite so effervescently happy to see D.B. (who introduces himself to us as Dylan Crandall) as he is to see House. House pretends not to know Crandall for a few cruel seconds before deigning to flash a smile at his friend and make fun of his gullible ways.