Chase is in the middle of Leona's liver biopsy when House pages Foreman, ordering him to stop it.
The Cottages report to House's office, where they find their boss listening to Jesse Baker on his record player. He urges them to listen, and Foreman begs him to tell them that he didn't stop a biopsy to make them listen to music. House says that the liver biopsy is actually unnecessary, and would have been fatal. Kind of like that bone marrow replacement, except even more dangerous. Nice going with that, guys. When the song gets to the part where Jesse starts yelling at people, Foreman loses his patience. But House says that Jesse was playing way too well for him to have been on any drugs: "Something [else] was screwing with his personality." Additionally, Jesse was yelling about his piano being out of tune when it actually was not, so House thinks that whatever was making him an asshole was also screwing with his aural perception. And if you add those things to the liver disease that killed Jesse, you get hemochromatosis. Which is genetic. House is apparently much quicker to believe that Leona is biologically related to Jesse than he is to believe she's related to Crandall. Cameron is about to test Leona's blood for iron, but House again says he has a quicker way. Maybe this time he'll break her entire arm.
House and the Cottages arrive at Leona's bedside and note that her skin color is darker now than it is in a picture of her from three years ago in Crandall's book. It doesn't make any sense that the picture would be in there, since Crandall said that Leona's mother didn't tell him about Leona because of how his book trashed her and her father, which would indicate that the book was published around the time Leona was born and not thirteen years later. This storyline doesn't make any sense anymore and I don't care about it. More House-Cuddy time, please! Anyway, hemochromatosis causes the skin to darken, and Leona's skin is definitely darker than it was just a few years ago. Which is fine, except for the fact that hereditary hemochromatosis almost never shows up until well into adulthood. Like when you're Jesse's age. So this still doesn't make sense. But Cameron smiles because she likes it when her boss is right. House orders the Cottages to find the iron deposit in Leona's liver and treat it with deferoxamine. Leona will be fine by lunchtime. Which is good, because House is hoping to score a free lunch off Wilson by telling him about the time he tied a teenage girl to a bed and then broke her finger for no reason.