Meanwhile, House has taken up residence in Cuddy's office. He's interviewing a bright young man to be his new intern. Cuddy enters the office and is surprised to see House there, and to hear that he's looking for an intern. She greets the guy, who laughs ridiculously as he shakes her hand. He apologizes, saying that he laughs when he's nervous. He tells Cuddy that he's interested in CANCER! and INFECTIOUS DISEASE! for his medical career. "The big devils!" he adds. He laughs and snorts again, and House asks him what kind of music he likes. Donor 613 says he likes Mozart. A lot. Cuddy's jaw drops and she leaves the office, being sure to open the desk drawer positioned at House's crotch quickly and strongly before she does. Don't hit him there too hard, Cuddy, or he won't be able to donate to your cause, which is where this storyline seems to be headed.

Chase hooks Leona up to the deferoxamine, promising that the treatment will be "quick and painless." Yeah, well, that's House said, and that didn't quite work out. Indeed, the Magic School Bus Cam goes into Leona's veins, where chunks of iron and/or deferoxamine are ripping holes through Leona's lungs. Obviously, this is bad news. The monitors respond accordingly. Chase rushes over to intubate Leona, who is no longer able to breathe.

"Her lungs are swiss cheese," Chase informs the crew of Leona's current condition. Great job, guys. The deferoxamine treatment has killed Leona, whose time, Chase says, is "basically up." House blames this on a flaw in the scientific method, because this means he didn't do anything wrong, just like how Crandall's girlfriend was solely at fault for cheating on him with House. While House paces and then sits to rub his leg, the Cottages go over what could have drawn all that iron into Leona's lungs and caused this whole mess. Her two-way digestive system can be blamed for the iron's going into her lungs instead of through her intestines to be disposed of as normal waste, but what made the iron rip through the lungs that way? Foreman comes up with an iron-loving fungus that bound to the iron. But there's a problem: if it is a fungus, they don't have time to figure out which one. House tells them to treat Leona for the most common fungus -- aspergillus -- and hope they're right. You know, like how they treated that autoimmune disease she didn't have and almost gave her a liver biopsy that would have killed her. Hooray for the guess-and-check method!