Wilson goes to House, who brags about how his latest patient had a screw removed from his lung. How did the screw get in the lung in the first place? Surely he didn't inhale it. Unless it was a very tiny screw. Anyway, he's still not better, which House claims he's telling Wilson to make some kind of point that Wilson's idea to double Tucker's chemo dose is a stupid one. Wilson thinks it'll thwart Tucker's chemo resistance and that he's just thinking like House. House reminds him that Wilson is Wilson and House is House. "I can handle when things go wrong. You can't," House says. Yes, because House really handles things so well. But I guess he means when things go wrong with the patients that he doesn't care about.
Wilson tells Tucker, Melissa, and Emily about his wacky double chemo plan and how dangerous it could be. But it could also save Tucker's life. Tucker asks Melissa what he should do. She says he should call his girlfriend. "You're my family. I'm sorry I forgot that," Tucker says. I guess the hot young girlfriend isn't quite as appealing now. Meanwhile, Emily is thrilled to see her parents reunited and says that Tucker should do the double chemo because if it works then they'll have Tucker with them for as long as possible. Of course, it could also means he'll be with them for a lot less time, but no one really thinks about that. Wilson hooks up the double chemo.
Time passes, and what do you know? Tucker's arm is moving and he's feeling cancer-free! Everyone is happy until Wilson notices that Tucker's eyes are looking very orange. Uh oh.
House enters the lab to find Hadley and Taub discussing how their latest patient is a dead man and Wilson looking terribly sad in front of a microscope. House quickly informs Taub and Hadley he isn't in there for them -- he's there for Wilson. Wilson says the double chemo cured Tucker's cancer, but it also fried his liver. In just 24 hours, half of it has died. Hadley and Taub respect Wilson's ability to destroy organs. House is very supportive of his devastated friend and says that this will serve as a good lesson to everyone else to never double a chemotherapy dose. By the way, what happened to the blood brain barrier? Didn't they say that the cancer couldn't get to the rest of Tucker's body because of it? And they were administering the chemo directly to his brain, so wouldn't that mean the chemo couldn't get to the liver?