Collier is on her phone with someone, saying she'll know more later. If Sean's hacker pal could track Vicky's phone, I don't see why the baddies can't track Collier's phone. We know they're powerful enough to tap the phone of the Yuma FBI office. Leila busts into the room to shout at Carter about her sister. Carter claims he doesn't know anything, so Leila digs her hands into his gaping broken-leg wound. Ick! It's all gross and bloody and sticky! Oh, and it's not good for Carter either. He recovers enough to tell her she should blame her father. "He's no angel. The way I heard it, he brought this on himself." That's nice and vague.
Police cars! Sirens! Screeching to a halt! Confused baristas! We have left the motel to return to Washington and the Search for Sophia. Simon and a flunkie discuss the situation. They have forty-three extra targets, so they're going to need to shut down the coffee shop and keep everyone there. There's a discussion about what cover story they should use, since the old Homeland Security dodge doesn't work as well as it used to. They decide they'll just have to make it sound convincing. This whole time, they're maybe two feet away from the people they're about to use this story on. Luckily, none of them show the slightest interest in listening in. Also, no one appears to remember that Simon was in there a few minutes earlier tampering with the milk. I can only assume that these people live every day of their lives in a world of ridiculous complications and plot holes, so they've decided to notice as few things as possible. Simon has some of his men look for Sophia on foot, while the others lock down the coffee shop.
Sophia walks through the city and is momentarily distracted by (PLOT POINT ALERT) an angry dog. So either They are mortally afraid of dogs or dogs instinctively hate them. Maybe they're vampires! That would explain why they landed in Alaska, because it has really long nights.
In the Situation Room, Sterling wants to override all traffic cameras and CCTV. Wait, isn't CCTV closed-circuit? So it's not actually connected to anything you can take over. That aside, this seems like the sort of thing you should have done as soon as you knew you were going to be tracking someone through the city. Just then! A man comes in to tell Sterling that whoever dosed the coffee shop did it with supplies from the government's armory. The impression I get is that they keep the secret radioactive isotope supplies in the White House itself. And only people on the field team have access to it, although they don't have specific records on who accessed it. But since it's highly radioactive, it should be fairly easy to tell who handled it. The man calls Simon and tells him to gather up his men. Now? The men who are looking for Sophia?