The show reminds me a little of Garth Marenghi's Darkplace (if you haven't watched that, please don't talk to me until you do) except instead of British people and ghosts and a haunted hospital, we have Jack Black as a former astronaut whose brain expanded to three times its normal size when he got too close to the sun on a mission, Jack's talking motorcycle Heat Vision (voiced by Owen Wilson) who inexplicably used to be his unemployed roommate, and Ron Silver, who plays himself and also NASA's bad guy hired gun. How Fox didn't pick up this gem back in the day is one of the enduring mysteries of television, but I suspect that it has something to do with the fact that it showed potential for being good. Take a look at this incredible episode featuring a not-yet-frightening-looking Christine Taylor as the foxy sheriff and Victor Schiavelli (R.I.P.) as the line-cook-turned-alien Paragon. Friggin' awesome.
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