I say we keep the show in Miami (say it thrice!), and in the house we have recent widows:

From Arrested Development, Gangy!
From Gilmore Girls, Emily Gilmore!
From Castle, Castle's graydar-casting, drink-swilling, show tune-belting mom, Martha! (If you haven't seen the show but are a fan of all things fabulous mature woman, I highly recommend you check it out for her alone.)
From Two and a Half Men, Evelyn Harper! (Again, if you don't watch the show, first of all I don't blame you, but she's played by Holland Taylor, who is marvelous no matter what she's in.)

Recurring guest stars:

Gangy's evil twin, from 90210, Tabitha Wilson!
Martha's Manhattan associate of scandal, from Heroes, Angela Petrelli!
Evelyn's jazzercise buddy, from Burn Notice, Madeline Westen!

So yeah, Angel needs to monitor my sugar intake better from now on. But seriously, who would you like to see on this fictional show that would never happen in a million years? I'm thinking about doing a follow-up post about their rotating roster of mature beaus as well, so leave your bids for them below too!