10. Supernatural
Two cute brothers roaming the Midwest fighting demons may not seem like it can be improved upon, but what if they were two tough sisters? Eliza Dushku and Eliza Coupe would bring the fighting and the funny, respectively.

9. Dexter
A serial killer who also investigates crime scenes can be any gender, but having a female killer would only make things that much more interesting when she marries her boyfriend and gets pregnant. Jaime Ray Newman (formerly of Eastwick) might be perfect, since she seems deceptively innocent, but with a wicked streak.

8. Buffy the Vampire Slayer/Angel
We watched Buffy evolve from a slightly clueless cheerleader-type to a tortured parental figure, so why not do the same with a dumb-as-rocks jock? And of course, it would eventually spin off a series about a brooding lady vampire, helping the innocent on the streets of Los Angeles while engaged in an illicit relationship with a boy 100 years her junior. Steven R. McQueen and Michelle Ryan, these parts have your names written all over them.

7. Mercy
Male nurses are almost as common as female ones nowadays, but there's still somewhat of a stigma attached. A show about three of them at one hospital could split its time between showing them kicking ass at their jobs and showing them kicking the asses of doctors and bar drunks who belittle their chosen careers.

6. The Mentalist
Simon Baker is charming as former fake psychic working for the California Bureau of Investigations (a fake law-enforcement agency). But a fortune-teller who claims to commune with the spirits could probably get even more answers out of suspects just by sneaking a peek in their wallets. Lucy Liu just saw her second series in a row tank, but maybe she can see herself solving crimes?

5. Desperate Housewives
With folks getting laid off left and right, isn't it time stay-at-home dads got the spotlight? Put four or five reasonably desperate househusbands on the same block, and see what sort of hijinks they get up to while their wives are at work.

4. The Big Bang Theory
Four nerd-girl scientists who sit around watching movies, playing video games and lusting after the hottie who lives across the hall? Where do we send our script? Rumer Willis seems to make her living playing nerds -- get her off 90210 and back into the lab, stat.

3. House
Crotchety male doctors are a dime-a-dozen, but Nurse Jackie opened our eyes to the magic of a cranky nurse. Let's give a female M.D. a limp, a painkiller addiction, a God complex and zero interpersonal skills. Felicity Huffman could nail that role, if she wasn't trapped on Wisteria Lane.

2. America's Next Top Model
The co-ed Make me a Supermodel gave us a glimpse of what a male modeling competition would look like, but why not go the whole distance? Put 13 hot guys in a house and see if they fight over who does the dishes -- or anything, for that matter.

1. 24
Jack Bauer is a living weapon, but anything he can do, a woman can do backwards and in high heels. Sure, Jennifer Garner kicked a lot of ass on Alias, but our Lady Bauer would never be caught dead wearing a pink wig. Give us a buff, kick-ass woman who can take out a terrorist cell single-handedly and won't stop sawing off people's heads until her 24 hours are up. Is Michelle Rodriguez still free?

What shows would you like to see change sexes? Bend your gender below.